Yes, it is possible to do something with nodes and ETH staked on them. This could include running a node to participate in a blockchain network, or running a masternode to earn rewards for helping to secure the network. However, there are risks associated with staking ETH and running nodes. These risks include the potential for your ETH to be stolen or lost if the node is hacked, or if the network is subject to a 51% attack. Additionally, there is the risk of not earning the expected rewards, or of the rewards not being worth the effort or cost associated with running a node. Thus, it is important to weigh the risks and rewards when considering whether to stake ETH or run a node.