It is possible to set custom slippage settings on aggregators like 1inch, which have a default setting of 0.50%. Depending on the amount of slippage you set, it can affect the level of "sandwiching" you experience when using the aggregator. If you set the slippage to a higher level, it could lead to more sandwiching, as the aggregator will be searching for more favorable prices from the available exchanges and liquidity pools, which could result in wider spreads. However, if you set the slippage to a lower level, it could lead to less sandwiching, as the aggregator will be searching for the best prices, which could result in narrower spreads. Ultimately, it will depend on the current market conditions and the amount of slippage you set.