No, first generation ETH DeFi and NFTs did not turn big profits the same cycle as they were born. This is because DeFi and NFTs are both relatively new technologies that are still being developed and refined. As such, they are not yet mature enough to generate consistent and reliable returns. Furthermore, the cryptocurrency markets are highly volatile and unpredictable, so it is difficult to make accurate predictions about the potential profits of any given asset. Additionally, the liquidity of the markets is still relatively low, meaning that it can be difficult to enter and exit positions quickly. All of these factors make it difficult for first generation ETH DeFi and NFTs to generate consistent, reliable returns in the same cycle as they were born.